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The identification of novel biomarkers, such as melatonin metabolites, oxidative catabolites, DNA methylation patterns, and circulating miRNAs, represents a critical step toward developing reliable tools for early detection and individualized risk stratification 2

Moreover, the increased risk of dehydration, electrolyte imbalance, hyperlipidemia, and kidney stone formation is of particular concern in older adults with comorbidities, including cardiovascular and renal disease

doi:10.1016/j.jep.2016.01.025 2025 The Author(s)

Do not expose to direct sunlight or store near heat source

Global disparities of cancer and its projected burden in 2050